lissencephaly type 1 (classic lissencephaly)

Pathology

• microcephaly & a thickened poorly organized cortex with 4 rather than 6 layers
• enlarged & dysmorphic ventricles & often hypoplasia of the corpus callosum

Genetics

• associated with defects in PAFAH1B1

More general terms

• lissencephaly; agyria

Database

• OMIM: https://mirror.omim.org/entry/607432