penciclovir (Denavir)

Indications

• Herpes labialis

Dosage

topical agent: apply cream every 2 hours while awake for 4 days

2 gram tubes, 10 mg/g.

Pharmacokinetics

• 1/2life of penciclovir is 2-3 hours
• > 90% of penciclovir is eliminated unchanged in the urine

elimination via kidney

Laboratory

• penciclovir in blood
• penciclovir in serum/plasma

Mechanism of action

• famciclovir (Famvir) is rapidly deacylated & oxidized to penciclovir, which provides antiviral activity
• penciclovir is converted intracellularly by viral thymidine kinase to penciclovir triphosphate
• penciclovir triphosphate inhibits viral DNA synthesis

More general terms

• antiviral agent

Additional terms

• famciclovir (Famvir)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4725
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5281036
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=656702
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5282475