fosfomycin (Monurol, Phosphonemycin)
Jump to navigation
Jump to search
Indications
- simple urinary tract infection (UTI), including UTI due to multidrug-resistant gram negative bacteria
Contraindications
- pyelonephritis (inadequate renal tissue levels)[4]
Dosage
- 3 g packet single oral dose[5], 2nd dose on day 5 for complicated UTI
- 1-16 g/day IV (only available PO in U.S.)
Antimicrobial activity
- gram-positive bacteria, including MRSA & VRE
- gram-negative bacteria, including multidrug-resistant gram negative bacteria[3]
Adverse effects
Notes
- less effective & more expensive than nitrofurantoin or TMP/SMX (Bactrim)[4]
- as safe & effective as other antibiotics to treat women with uncomplicated urinary tract infections[5]
More general terms
References
- ↑ Reeves DS. Treatment of bacteriuria in pregnancy with single dose fosfomycin trometamol: a review. Infection. 1992;20 Suppl 4:S313-6. Review. PMID: https://pubmed.ncbi.nlm.nih.gov/1294525
- ↑ Bayrak O, Cimentepe E, Inegol I, Atmaca AF, Duvan CI, Koc A, Turhan NO. Is single-dose fosfomycin trometamol a good alternative for asymptomatic bacteriuria in the second trimester of pregnancy? Int Urogynecol J Pelvic Floor Dysfunct. 2006 Aug 29; PMID: https://pubmed.ncbi.nlm.nih.gov/16941068
- ↑ 3.0 3.1 Medical Knowledge Self Assessment Program (MKSAP) 16, 18. American College of Physicians, Philadelphia 2012, 2018.
- ↑ 4.0 4.1 4.2 NEJM Knowledge+ Question of the Week. Jan 30, 2018 https://knowledgeplus.nejm.org/question-of-week/1569/
- ↑ 5.0 5.1 5.2 Verma T, Manhas GS, Manhas RS. Efficacy and Safety of Single-dose Fosfomycin for Uncomplicated Urinary Tract Infection in Women: Systematic Review and Meta-analysis. J Midlife Health. 2025 Apr-Jun;16(2):124-136. PMID: https://pubmed.ncbi.nlm.nih.gov/40636841 PMCID: PMC12240282 Free PMC article. Review. https://pmc.ncbi.nlm.nih.gov/articles/PMC12240282/
Database
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=73491
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3417
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=54331
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=93095
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=446987
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=31669
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441395
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4801