diphenoxylate

Introduction

Used in combination with atropine in Lomotil.

Pharmacokinetics

• good bioavailability
• extensively metabolized to an inactive metabolite
• elimination 1/2life is 12-14 hours
• excreted primarily in urine

elimination via liver

1/2life = 12-14 hours

Mechanism of action

• constipating meperidine congener
• lacks analgesic activity

More general terms

• anti-motility agent; antiperistaltic agent

Component of

• atropine/diphenoxylate (Lomotil, Lonox)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=13505
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=64662
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=19650