nifurtimox (Lampit)

Indications

Chagas disease (Trypanosoma cruzi)

• 8-10 mg/kg/day for adults
• 12.5-15 mg/kg/day for adolescents
• 15-20 mg/kg/day for children ages 1-10 years
• doses given orally, divided QID
• therapy should be continued to 90-120 days
• available from CDC (707 639-3670)

Adverse effects

• abdominal pain
• anorexia
• nausea/vomiting
• weight loss
• neurologic manifestations:
  • restlessness
  • disorientation
  • insomnia
  • twitching
  • paresthesia
  • polyneuritis
  • seizures
• symptoms, generally resolve when dosage is reduced or therapy is discontinued

More general terms

• antiprotozoal agent

Additional terms

• Chagas disease

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=31772