benznidazole
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Indications
Dosage
- 5-8 mg/kg/day PO every 12 hours for 60 days
Adverse effects
- polyneuropathy
- rash
- granulocytopenia
- angioedema[4]
- symptoms, generally resolve when dosage is reduced or therapy is discontinued
Mechanism of action
- nitroimidazole antimicrobial
- generates radical species in both aerobic & anaerobic conditions capable of damaging parasitic DNA
- inhibits DNA, RNA, and protein synthesis within the Trypanosoma cruzi parasite.
More general terms
Additional terms
References
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1194
- ↑ Viotti R, Vigliano C, Lococo B, Bertocchi G, Petti M, Alvarez MG, Postan M, Armenti A. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med. 2006 May 16;144(10):724-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16702588
Pinto Dias JC. The treatment of Chagas disease (South American trypanosomiasis). Ann Intern Med. 2006 May 16;144(10):772-4. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16702594 - ↑ 3.0 3.1 FDA News Release. Aug 29, 2017 FDA approves first U.S. treatment for Chagas disease. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm573942.htm
Windle ML. FDA New Drug and Biologic Approvals -- 2017 Year-in-Review Medscape - Jan 11, 2018. https://reference.medscape.com/viewarticle/890871
U.S. Food and Drug Administration. Novel Drug Approvals for 2017. https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DrugInnovation/ucm537040.htm - ↑ 4.0 4.1 Rothaus C Under Our Very Eyes. NEJM REsident 360. March 4, 2020 https://resident360.nejm.org/clinical-pearls/under-our-very-eyes
- ↑ Benznidazole prescribing information. Exeltis USA, Inc. Florham Park, NJ. August, 2017. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209570lbl.pdf