ciclopirox (Loprox, Penlac nail lacquer, Batrfen)

Introduction

Tradenames: Loprox, Penlac nail lacquer. (ciclopirox olamine)

Indications

• treatment of tinea, cutaneous candidiasis, dermatophytes
• topical treatment of onychomycosis of fingernails & toenails without lunula involvement due to Trichophyton rubrum
• treatment of seborrheic dermatitis, dandruff

Dosage

• adult & chidren > 10 years
  • apply BID
  • discontinue & re-evaluate if no improvement in 4 weeks
  • 12% success rate (onychomycosis) after 1 year of daily use

Cream: 1%, 15 & 30 g.

Lotion: 1%, 30 mL.

Adverse effects

• not common (1-10%)
  • irritation, erythema, pain or burning, worsening of clinical condition

More general terms

• antifungal agent

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=38911
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2749