tiopronin; alpha-mercaptopropionylglycine (Tiola)

Introduction

Tradenames: Tiola. (alpha-mercaptopropionyl glycine)

Indications

• prevention of cystine renal stones in patients with severe homozygous cystinuria with urinary cystine > 500 mg/day resistant to treatment with high fluid intake, alkali, & diet modification or have had adverse effects with penicillamine

Dosage

• start 800 mg/day
• average effective dose is 1000 mg/day

Tabs: 100 mg

More general terms

• thiol; sulhydryl compound; mercaptan
• metabolic agent (metabolic modifier)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5483
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=83819
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=83913
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=83912