pure autonomic failure (PAF)
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Introduction
slowly progressive degeneration of the autonomic nervous system.
Epidemiology
sporadic, adult onset
Pathology
- Lewy bodies/inclusions
- brainstem
- pre- & post-ganglionic autonomic neurons
- peripheral sympathetic nerves & parasympathetic nerves
Clinical manifestations
- isolated autonomic impairment
Complications
- increased risk of Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy[2]
More general terms
References
- ↑ Kaufmann H, Biaggioni I. Autonomic Failure in Neurodegenerative Disorders Seminars in Neurology 23(4):351-363, 2003 PMID: https://pubmed.ncbi.nlm.nih.gov/15088256
- ↑ 2.0 2.1 George J Is Pure Autonomic Failure a Warning Sign for Parkinson's? What a New Study Shows. High conversion rates to Parkinson's, dementia with Lewy bodies, or multiple system atrophy MedPage Today, May 4, 2026 https://www.medpagetoday.com/neurology/parkinsonsdisease/121107
Virameteekul S, Bonini I, Campese N, et al Phenoconversion in Pure Autonomic Failure. A Systematic Review and Meta-Analysis. JAMA Neurol. 2026. May 4:e260989 PMID: https://pubmed.ncbi.nlm.nih.gov/42081229 https://jamanetwork.com/journals/jamaneurology/fullarticle/2848689