follicle center lymphoma, grade I (follicular small cleaved cell lymphoma)
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Introduction
Classification
- working formulation
- follicular, predominantly small cleaved cell
- Rappaport
- nodular, poorly differentiated lymphocytic
- Lukes-Collins
- FCC*, small cleaved
- Kiel
* FCC: follicular center cells
Epidemiology
- most common form of follicular lymphoma
Pathology
- neoplastic B-cells
- small, cleaved cells within normal germinal centers
- slightly larger than normal lymphocytes
- scantly cytoplasm
- irregular, cleaved nuclear contour*
- prominent clefts, indentations, linear infoldings
- course & condensed nuclear chromatin
- indistinct nucleoli
- mitoses are infrequent
- may be scattered large cleaved or non-cleaved cells within the nodule (< 20% of cells)
* distinguishing feature of neoplastic cells
More general terms
Additional terms
References
- ↑ Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 712-713
- ↑ Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994 Sep 1;84(5):1361-92. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8068936