glomangioma; glomus tumor; glomuvenous malformation

Introduction

A tumor of the glomus body.

Pathology

• smooth-muscle-like glomus cells in the tunica media surrounding distended vascular lumens

Genetics

• mutations in glomulin gene

Clinical manifestations

• exquisitely tender subungual papule or nodule
• paroxysmal painful attacks, especially elicited by exposure to cold
• generally occur as solitary subungual tumors
• may occur as multiple papules or nodules (glomangiomas)
  • glomangioma do not occur underneath the nail
  • may occur anywhere on the skin surface
  • largely vascular rather than solid as a solitary lesions
• may also be found on the tympanic membrane (glomus tympanicum)

More general terms

• pericytic neoplasm

More specific terms

• aural glomus tumor; glomus tympanicum
• glomus jugulare tumor; jugulotympanic paraganglioma

Additional terms

• glomulin (GLMN FK506-binding protein-associated protein, 48 kD)

Patient information

glomangioma patient information

Database

• OMIM: https://mirror.omim.org/entry/138000