embryonal sarcoma of liver

Etiology

unknown

Epidemiology

• 6% of primary hepatic tumors of childhood
• occurs between 5 and 20 years of age
• rarely middle and old age

Pathology

• malignant stellate cells or spindle cells
• compactly or loosely arranged in myxoid stroma
• multinucleated giant cells (may be multinucleated)
• cytoplasmic eosinophilic globules of variable size
  • PAS positive, diastase resistant
  • express alpha-1-antitrypsin
• entrapped bile ducts and hepatocellular elements

Clinical manifestations

• abdominal enlargement
• fever
• weight loss
• nonspecific gastrointestinal complaints

More general terms

• embryonal sarcoma
• liver neoplasm