endothelin-converting enzyme-like 1 (Xce protein, ECEL1, XCE, UNQ2431/PRO4991)

Function

• degradation of peptide hormones
• inactivation of neuronal peptides.

Structure

• binds 1 Zn+2
• N-glycosylated

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in CNS, including putamen, spinal cord, medulla & subthalamic nucleus > amygdala, caudate, thalamus > substantia nigra, cerebellum, cortex, corpus callosum, hippocampus
• also expressed in uterine subepithelial cells, renal blood vessels, pancreas, skeletal muscle

More general terms

• metalloprotease
• glycoprotein
• membrane

Database

• OMIM: https://mirror.omim.org/entry/605896
• UniProt: http://www.uniprot.org/uniprot/O95672.html