LCCL domain

Introduction

Named for proteins found to contain it:

• Limulus factor C
• cochlin
• late gestation lung protein Lgl1

Domain of about 100 amino acid residues domain with C-terminal region that contains a conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. It is an autonomously folding domain used for the construction of modular proteins through exon-shuffling.

It may be involved in lipopolysaccharide (LPS) binding.

The LCCL domain is found in association with:

• complement B-type domains
• C-type lectin domains
• von Willebrand type A domains
• CUB domains
• discoidin lectin domains
• CAP domains

Secondary structure prediction suggests that the LCCL domain contains 6 beta strands & 2 alpha helices

More general terms

• domain