Scianna blood group locus

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Introduction

ERMAP is responsible for the Scianna/Radin blood group system consisting of 7 different antigens. The Sc1 & Sc2 antigens result from a single variation in position 57; Arg-57 corresponds to the Sc2 antigen & Gly-57 to the Sc1 antigen. The Sc2 antigen is rare (< 1%); Sc1 is more frequent. Sc3 represents individuals homozygous for a null allele encoding a truncated protein lacking its extracellular part (Sc-3). The Sc4 antigen corresponeds to the Radin blood group antigen. It is due to a single variation in position 60; Ala-60 corresponds to Sc4/Rd(+), the antigenic form of the protein. Sc4 is found in < 1% of the population. Sc5/STAR, Sc6/SCER & Sc7/SCAN antigens are due to single variations in positions 47, 81 & 35 respectively.

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