paraneoplastic antigen Ma1; neuron- & testis-specific protein 1; 37 kD neuronal protein (PNMA1, MA1)
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Structure
belongs to the PNMA family
Compartment
- nucleus, nucleolus
- in tumor cells, it is cytoplasmic
Expression
- testis & brain specific
- in some cancer patients, it is also specifically expressed by the paraneoplastic tumor cells
Pathology
- antibodies against PNMA1 (anti-Ma1) are present in sera from patients suffering of paraneoplastic neurologic syndromes