Scl-70 antigen

Introduction

Spontaneous degradation product of topoisomerase I.

Pathology

• antibodies against Scl present in 20-50% of patients with diffuse scleroderma
• Scl-70 antigen displays a punctate distribution within the nucleus

More general terms

• protein degradation product
• antigen

Additional terms

• Scl-70 (anti-topoisomerase) Ab in serum
• scleroderma (diffuse cutaneous systemic sclerosis)
• topoisomerase-1 (TOP1)