Na+/K+/Ca+2 exchanger 2; Na+/K+/Ca(2+)-exchange protein 2; retinal cone Na-Ca+K exchanger; solute carrier family 24 member 2 (SLC24A2 NCKX2)

Function

• component of the visual transduction cascade
• controls Ca+2 concentration of outer segments during light & darkness
  • light causes a rapid lowering of cytosolic free Ca+2 in the outer segment of both retinal rod & cone photoreceptors
  • the light-induced lowering of Ca+2 is caused by extrusion of Ca+2 via SLC24A2, thus its role in light adaptation
  • transports 1 Ca+2 & 1 K+ in exchange for 4 Na+

Structure

• belongs to the Na+/K+/Ca+2 exchanger family, SLC24A subfamily

Compartment

membrane

Alternative splicing

named isoforms=2

More general terms

• solute carrier family 24 (SLC24, SLC24A)
• transmembrane 11 protein
• glycoprotein
• Na+/K+/Ca+2 antiporter or exchanger

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25769
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25769
• OMIM: https://mirror.omim.org/entry/609838
• UniProt: http://www.uniprot.org/uniprot/Q9UI40.html