calcipressin-1; adapt78; Down syndrome critical region protein 1; myocyte-enriched calcineurin-interacting protein 1; MCIP1; regulator of calcineurin 1 (RCAN1, ADAPT78, CSP1, DSC1, DSCR1)

Function

• inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A
• could play a role during central nervous system development

Structure

belongs to the RCAN family

Alternative splicing

named isoforms=4

Expression

• highly expressed heart, brain & skeletal muscle
• also expressed in all other tissues
• induced by Ca+2

More general terms

• calcipressin
• Down syndrome critical region protein

Additional terms

• calcineurin; serine/threonine protein phosphatase 3 (formerly PP2B)
• Down's syndrome

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1827
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1827
• OMIM: https://mirror.omim.org/entry/602917
• UniProt: http://www.uniprot.org/uniprot/P53805.html