transforming growth factor beta-4; Left-right determination factor 2; endometrial bleeding-associated factor; Left-right determination factor A; protein lefty-2; protein lefty-A; TGF-beta-4 (LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, PSEC0024)

Function

• required for left-right (L-R) asymmetry determination of organ systems in mammals
• may play a role in endometrial bleeding
• processing of the protein may occur at the 2nd R-X-X-R site located at aa-residues 132-135
• arocessing appears to be cell-type specific

Structure

belongs to the TGF-beta family

Compartment

secreted

Expression

• mesenchymal cells of the endometrial stroma
• transiently expressed before & during menstrual bleeding

Pathology

• mutations associated with left-right axis malformations
• strong expression in endometrium associated with abnormal endometrial bleeding

More general terms

• transforming growth factor [TGF]-beta

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7044
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7044
• OMIM: https://mirror.omim.org/entry/601877
• UniProt: http://www.uniprot.org/uniprot/O00292.html