guanylate cyclase 2F (retinal guanylyl cyclase 2, GUCY2F)

Function

• role in rods &/or cones of photoreceptors
• enzyme involved resynthesis of cGMP required for recovery of dark state after phototransduction
• activated by GCAP-1, inhibited by Ca+2

GTP  <-->  3',5'-cyclic GMP + diphosphate

Compartment

membrane

Expression

• expressed in retina
• localized exclusively in the outer nuclear layer & inner segments of the rod & cone photoreceptor cells

More general terms

• guanyl cyclase or guanylate cyclase

Database

• UniProt: http://www.uniprot.org/uniprot/P51841.html
• OMIM: https://mirror.omim.org/entry/300041
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2986