Phosphatidylinositol-4-phosphate 5-kinase-like protein 1 (PtdIns(4)P-5-kinase-like protein 1, PI(4)P 5-kinase-like protein 1, PIP5KL1)

Function

• may act as a scaffold to localize & regulate type 1 PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling & scaffold protein recruitment & conversion to PI(3,4,5)P3
• heterodimerizes with other type 1 PI-4-phosphate 5-kinase
• unsure if the enzyme has intrinsic kinase activity

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
                  <-->
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Structure

contains 1 PI5K domain

Compartment

• cytoplasm, membrane
• localized to large cytoplasmic vesicular structures

Alternative splicing

named isoforms=2

More general terms

• phosphoinositide-5-kinase

Database

• UniProt: http://www.uniprot.org/uniprot/Q5T9C9.html