phosphatidylinositol-5-phosphate 4-kinase type-2 beta; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; diphosphoinositide kinase 2-beta; phosphatidylinositol-5-phosphate 4-kinase type 2 beta; PI(5)P 4-kinase type 2 beta; PIP4KII-beta; Ptdins(5)P-4-kinase isoform 2-beta (PIP4K2B, PIP5K2B)

Function

• role in the biosynthesis of phosphatidylinositol-4,5-bisphosphate
• binds TNFRSF1A

ATP + phosphatidylinositol 4-phosphate = ADP + phosphatidylinositol-4,5-bisphosphate

Structure

• homodimer
• contains 1 PIPK domain

Compartment

• endoplasmic reticulum membrane
• plasma membrane (putative)

Alternative splicing

named isoforms=2

Expression

• highly expressed in brain, heart, pancreas, skeletal muscle & kidney
• detected at lower levels in placenta, lung & liver

More general terms

• phosphoinositide-5-kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8396
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8396
• OMIM: https://mirror.omim.org/entry/603261
• UniProt: http://www.uniprot.org/uniprot/P78356.html