quinolinate phosphoribosyltransferase [decarboxylating] (nicotinate-nucleotide pyrophosphorylase [carboxylating])

Function

• cofactor biosynthesis; NAD+ biosynthesis
• kynurenine pathway, tryptophan to nicotinate-ribonucleotide, 7th (last) step
• nicotinate ribonucleotide from pyridine-2,3-dicarboxylate

nicotinate D-ribonucleotide + diphosphate + CO2
                  <-->
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate

Structure

belongs to the nadC/modD family

More general terms

• pentosyltransferase
• allosteric enzyme
• oligomerizing protein

Additional terms

• kynurenine pathway

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2347
• OMIM: https://mirror.omim.org/entry/606248
• UniProt: http://www.uniprot.org/uniprot/Q15274.html