metal transporter CNNM2 (cyclin-M2, ancient conserved domain-containing protein 2, CNNM2, ACDP2)

Function

• divalent metal cation transporter
• mediates transport of divalent metal cations in an order of Mg+2 > Co+2 > Mn+2 > Sr+2 > Ba+2 > Cu+2 > Fe+2 (putative)

Structure

• belongs to the ACDP family
• contains 1 CBS domain

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• widely expressed
• expressed at higher level in brain, kidney & placenta
• weakly expressed in skeletal muscle

Notes

• shares weak sequence similarity with the cyclin family, explaining its name; however, it has no cyclin-like function in vivo

More general terms

• carrier protein (transporter)
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/607803
• UniProt: http://www.uniprot.org/uniprot/Q9H8M5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54805