multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; LTC4 transporter (ABCC1, MRP, MRP1)

Function

• role in active transport of drugs into subcellular organelles
• may influence drug distribution indirectly
• confers resistance to anticancer drugs
• transports LTC4
• may protect milk against xenobiotics (putative)

Structure

• belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
• contains 2 ABC transmembrane type-1 domains
• contains 2 ABC transporter domains

Compartment

membrane

Alternative splicing

named isoforms=9

Additional isoforms seem to exist

Expression

• lung, testis & peripheral blood mononuclear cells

More general terms

• transmembrane 17 protein
• ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
• phosphoprotein
• glycoprotein

Additional terms

• leukotriene C4

Database

• OMIM: https://mirror.omim.org/entry/158343
• UniProt: http://www.uniprot.org/uniprot/P33527.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4363