adapter-related protein complex 4; HA4/AP4 adaptor complex

Function

• novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system

Structure

• heterotetramer of:
  • AP4E1 (epsilon-adaptin)
  • AP4B1 (beta-adaptin)
  • AP4M1 (my-adaptin)
  • AP4S1 (sigma-adaptin)

More general terms

• HA/AP adaptor complex