K+ channel subfamily N member 3; small conductance Ca+2-activated K+ channel protein 3; SK3; SKCa 3; SKCa3; KCa2.3 (KCNN3, K3)

Function

• voltage-independent K+ channel activated by intracellular Ca+2
• intermediate/small conductance
• activation is followed by membrane hyperpolarization
• regulates neuronal excitability by contributing to slow component of synaptic after hyperpolarization
• channel is blocked by apamin
• hetero-oligomer
• 4 channel subunits each of which binds a calmodulin subunit that regulates channel activity through Ca+2-binding

Structure

• belongs to the K+ channel KCNN family KCa2.3/KCNN3 subfamily

Compartment

membrane

Alternative splicing

named isoforms=2

Polymorphism

• 2nd poly-Gln region of KCNN3 is highly polymorphi
• number of Gln varies from 12-28

More general terms

• transmembrane 6 protein
• calmodulin binding protein
• K+ channel subfamily N

Component of

• Ca+2-activated K+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3782
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3782
• OMIM: https://mirror.omim.org/entry/602983
• UniProt: http://www.uniprot.org/uniprot/Q9UGI6.html