K+ channel subfamily N member 1; small conductance Ca+2-activated K+ channel protein 1; putative Gardos channel; SK1; SKCa 1; SKCa1; KCa2.1 (KCNN1, SK)

Function

• voltage-independent K+ channel activated by intracellular Ca+2
• intermediate/small conductance
• activation is followed by membrane hyperpolarization
• regulates neuronal excitability by contributing to slow component of synaptic after hyperpolarization
• channel is blocked by apamin
• hetero-oligomer
• 4 channel subunits each of which binds a calmodulin subunit that regulates channel activity through Ca+2-binding

Structure

• belongs to the K+ channel KCNN family
• KCa2.1/KCNN1 subfamily

Compartment

membrane

Alternative splicing

named isoforms=2

More general terms

• transmembrane 6 protein
• calmodulin binding protein
• K+ channel subfamily N

Component of

• Ca+2-activated K+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3780
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3780
• OMIM: https://mirror.omim.org/entry/602982
• UniProt: http://www.uniprot.org/uniprot/Q92952.html