chromatid-fiber
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Introduction
There are 5 levels of folding of DNA in eukaryotic chromosomes. The chromatid-fiber represents the 5th level of DNA folding. Nucleosomes (1st level of folding) are organized into solenoids (2nd level of folding). The solenoids in turn are folded into loops (3rd level of folding), which in turn form 6 loop rosette structures of 300 Kbp also known radial arrays (4th level of folding). The radial arrays further fold into coils which form chromatid fibers (250 X 700 nm) which form the chromosomal banding seen on chromosomal staining.
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References
- ↑ Manuelidis L. A view of interphase chromosomes. Science. 1990 Dec 14;250(4987):1533-40. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2274784
- ↑ Filipski J, Leblanc J, Youdale T, Sikorska M, Walker PR. Periodicity of DNA folding in higher order chromatin structures. EMBO J. 1990 Apr;9(4):1319-27. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2323342