Na+/iodide symporter (NIS, solute carrier family 5 member 5, SLC5A5)
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Function
- mediates iodide uptake in the thyroid gland
- symporter that concentrates iodide in thyroid follicular cells
- antibodies to the Na/I- symporter may occur in patients with Hashimoto's thyroiditis
Structure
Compartment
membrane
Expression
- expression is primarily in thyroid tissue
- lower extent in mammary gland & ovary
- expression is reduced in tumors
Pathology
- defects in SLC5A5 are the cause of congenital hypothyroidism due to dyshormonogenesis type 1
More general terms
References
- ↑ Journal Watch 20(18):144, 2000 Tazebay UH et al The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nature Medicine 6:871, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10932223
Daniels & Haber Nature Medicine 6:859, 2000 - ↑ Dai G et al, Cloning and characteristics of the thyroid iodide transporter. Nature 379:458, 1996 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8559252
- ↑ Eskandari S et al, Thyroid Na+/I- symporter. Mechanism, stoichiometry, and specificity. J Biol Chem 272(43):27230-8, 1997 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9341168
- ↑ UniProt http://www.uniprot.org/uniprot/Q92911.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC5A5