ficolin-1; collagen/fibrinogen domain-containing protein 1; ficolin-A; ficolin-alpha; M-ficolin (FCN1, FCNM)

Function

• role in serum exerting lectin activity
• binds GlcNAc
• interacts with elastin

Structure

• homopolymer
• belongs to the ficolin lectin family
• contains 1 collagen-like domain
• contains 1 fibrinogen C-terminal domain

Compartment

• secreted
• found on the monocyte surface

Expression

• expressed in peripheral blood leukocytes
• also detected in spleen, lung, & thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues
• not detected on lymphocytes or granulocytes

More general terms

• ficolin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2219
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2219
• OMIM: https://mirror.omim.org/entry/601252
• UniProt: http://www.uniprot.org/uniprot/O00602.html