Rho GDP-dissociation inhibitor 3 (Rho GDI 3, Rho-GDI gamma)

Function

• inhibits GDP/GTP exchange reaction of RhoB
• interacts specifically with GDP- & GTP-bound forms of post-translationally processed RhoB & RhoB proteins, both of which show growth-regulated expression in mammalian cells
• stimulates release of GDP-bound but not GTP-bound RhoB protein
• inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP

Structure

belongs to the Rho GDI family

Compartment

cytoplasm

Expression

expressed in pancreas & brain

More general terms

• rho/rac GDP dissociation inhibitor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=398
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:398
• OMIM: https://mirror.omim.org/entry/602844
• UniProt: http://www.uniprot.org/uniprot/Q99819.html