serpin B3; squamous cell carcinoma antigen 1; SCCA-1; protein T4-A (SERPINB3, SCCA, SCCA1)

Function

• may act as a protease inhibitor to modulate the host immune response against tumor cells

Structure

belongs to the serpin family, Ov-serpin subfamily

Compartment

• cytoplasm
• seems to also be secreted in plasma by cancerous cells but at a low level

Alternative splicing

named isoforms=2

Expression

• squamous cells
• expressed in some hepatocellular carcinoma (at protein level)
• expression is closely related to cellular differentiation in both normal & malignant squamous cells

More general terms

• serine protease inhibitor; serpin
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6317
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6317
• OMIM: https://mirror.omim.org/entry/600517
• UniProt: http://www.uniprot.org/uniprot/P29508.html