mitochondrial elongation factor G2; ribosome-releasing factor 2, mitochondrial; RRF2mt; elongation factor G 2, mitochondrial; EF-G2mt; mEF-G 2; elongation factor G2; hEFG2 (GFM2, EFG2, MSTP027)

Function

• mitochondrial GTPase
• mediates disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis
• acts in collaboration with MRRF
• GTP hydrolysis follows the ribosome disassembly & probably occurs on the ribosome large subunit
• not involved in GTP-dependent ribosomal translocation step during translation elongation

Structure

• belongs to the GTP-binding elongation factor family EF-G/EF-2 subfamily

Compartment

mitochondria (putative)

Alternative splicing

named isoforms=5

Expression

widely expressed

More general terms

• mitochondrial protein
• translation elongation factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84340
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84340
• OMIM: https://mirror.omim.org/entry/606544
• UniProt: http://www.uniprot.org/uniprot/Q969S9.html