mitochondrial elongation factor G1; elongation factor G, mitochondrial; EF-Gmt; elongation factor G 1, mitochondrial; mEF-G 1; elongation factor G1; hEFG1 (GFM1, EFG, EFG1, GFM)

Function

• mitochondrial GTPase
• catalyzes GTP-dependent ribosomal translocation step during translation elongation
• during this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site bound peptidyl-tRNA & P-site bound deacylated tRNA move to the P-site & E-site, respectively
• catalyzes the coordinated movement of the two tRNA molecules, the mRNA & conformational changes in the ribosome
• does not mediate the disassembly of ribosomes from mRNA at the termination of mitochondrial protein biosynthesis
• protein biosynthesis; polypeptide chain elongation

Structure

• belongs to the GTP-binding elongation factor family EF-G/EF-2 subfamily

Compartment

mitochondria (putative)

Alternative splicing

named isoforms=2

Pathology

• defects in GFM1 are the cause of combined oxidative phosphorylation deficiency type 1y

More general terms

• mitochondrial protein
• translation elongation factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85476
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85476
• OMIM: https://mirror.omim.org/entry/606639
• OMIM: https://mirror.omim.org/entry/609060
• UniProt: http://www.uniprot.org/uniprot/Q96RP9.html