elongation factor Ts, mitochondrial; EF-TsMt; EF-Ts (TSFM)

Function

• associates with the EF-Tu.GDP complex & induces exchange of GDP to GTP
• remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome

Structure

belongs to the EF-Ts family

Compartment

mitochondria

Alternative splicing

• named isoforms=2; position: 333:R->W (in COXPD3)

Expression

• expressed in all tissues
• highest expression in skeletal muscle, liver & kidney

Pathology

• defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3

More general terms

• mitochondrial protein
• translation elongation factor

Database

• UniProt: http://www.uniprot.org/uniprot/P43897.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10102
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10102
• OMIM: https://mirror.omim.org/entry/604723
• OMIM: https://mirror.omim.org/entry/610505