kynurenine-oxoglutarate transaminase 1 (kynurenine aminotransferase 1, KATI, glutamine-phenylpyruvate transaminase, glutamine transaminase K, GTK, cysteine-S-conjugate beta-lyase, CCBL1)

Function

• glutamine catabolism
• catalyzes irreversible transamination of L-tryptophan metabolite L-kinurenine to form kynurenic acid
• metabolizes cysteine conjugates of certain halogenated alkenes & alkanes to form reactive metabolites
• catalyzes the beta-elimination of S-conjugates & Se-conjugates of L-(seleno)cysteine, resulting in cleavage of the C-S or C-Se bond

L-kynurenine + 2-oxoglutarate
         <-->
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate

L-glutamine + phenylpyruvate
          <-->
2-oxoglutaramate + L-phenylalanine

RS-CH2-CH(NH3+)-COO-  <-->  RSH + NH3  + pyruvate

Cofactor: pyridoxal phosphate

Structure

• homodimer
• belongs to the class-1 pyridoxal-phosphate-dependent aminotransferase family

Compartment

cytoplasm

Alternative splicing

named isoforms=3

More general terms

• enzyme

Database

• OMIM: https://mirror.omim.org/entry/600547
• UniProt: http://www.uniprot.org/uniprot/Q16773.html