peroxisomal 2,4-dienoyl-CoA reductase (2,4-dienoyl-CoA reductase 2, pDCR, DECR2, PDCR)

Function

• auxiliary enzyme of beta-oxidation
• degradation of unsaturated fatty enoyl-CoA esters with double bonds in both even- & odd-numbered positions in peroxisome
• catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA
• activity towards short & medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid

Trans-2,3-didehydroacyl-CoA + NADP+
           <-->
trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH

Kinetic parameters:

• KM=59 uM for 2,4-hexadienoyl-CoA;
• KM=6 uM for 2,4-decadienoyl-CoA;
• KM=102 uM for 2,4,7,10,13,16,19-docosaheptaenoyl-CoA

Compartment

peroxisome

Alternative splicing

named isoforms=3

More general terms

• enzyme

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NUI1.html