protein spire homolog 2 (spir-2, SPIRE2, KIAA1832, SPIR2)

Function

• acts as a actin nucleation factor
• remains associated with the slow-growing pointed end of the new filament
• involved in vesicle transport processes providing a novel link between actin organization & intracellular transport (putative)

Structure

• binds to actin monomers via the WH2 domain
• the spir-box targets binding to intracellular membrane structures (putative)
• belongs to the spire family
• contains 3 WH2 domains

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=4

More general terms

• cytoskeletal protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8450
• UniProt: http://www.uniprot.org/uniprot/Q8WWL2.html