ermin (juxtanodin, JN, ERMN, KIAA1189)

Function

• role in cytoskeletal rearrangements during the late wrapping &/or compaction phases of myelinogenesis
• role in maintenance & stability of myelin sheath in the adult
• role in late-stage oligodendroglia maturation, myelin & Ranvier node formation during CNS development
• role in maintenance & plasticity of related structures in the mature CNS
• binds actin (putative)

Compartment

cytoplasm, cytoskeleton (putative)

Expression

• highly expressed in adult & fetal brain
• expressed at intermediate levels in the lung & liver

More general terms

• cytoskeletal protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5747
• UniProt: http://www.uniprot.org/uniprot/Q8TAM6.html