coiled-coil domain-containing protein 6; papillary thyroid carcinoma-encoded protein; protein H4 (CCDC6, D10S170, TST1)

Structure

• mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation

Compartment

• cytoplasm. cytoplasm, cytoskeleton (probable)

Expression

• ubiquitously expressed

Pathology

• defects in CCDC6 are a cause of thyroid papillary carcinoma
• chromosomal inversion inv(10)(q11.2;q21) involving CCDC6 & generation of the RET/CCDC6 (PTC1) oncogene is found in thyroid papillary carcinomas

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8030
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8030
• OMIM: https://mirror.omim.org/entry/188550
• OMIM: https://mirror.omim.org/entry/601985
• UniProt: http://www.uniprot.org/uniprot/Q16204.html