smoothelin (SMTN SMSMO)

Function

• structural protein of the cytoskeleton
• isoforms L1 & L2 phosphorylated on Thr-373

Structure

• belongs to the smoothelin family
• contains 1 CH (calponin-homology) domain

Compartment

• cytoplasm, cytoskeleton
• exhibits a filamentous organization

Alternative splicing

• named isoforms=6' A, B, B2, B3, L1, L2
• additional isoforms seem to exist

Expression

• expressed in smooth muscle; contractile or vascular

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6525
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6525
• OMIM: https://mirror.omim.org/entry/602127
• UniProt: http://www.uniprot.org/uniprot/P53814.html