adseverin; scinderin (SCIN, KIAA1905)

Function

• Ca+2-dependent actin filament-severing protein
• remains tightly bound to barbed end of F-actin after severing filament
• presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane
• in vitro, has barbed end capping & nucleating activities in the presence of Ca+2

Structure

• belongs to the villin/gelsolin family
• contains 6 gelsolin-like repeats

Compartment

cytoplasm, cytoskeleton

Alternative splicing

named isoforms=2

Expression

expressed in secretory cells

Comparative biology

• Severin in Dictostelium homolog

More general terms

• cytoskeletal protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y6U3.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85477
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85477