exostosin-like 2; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; alpha-1,4-N-acetylhexosaminyltransferase EXTL2; alpha-galNAcT EXTL2; EXT-related protein 2; contains: processed exostosin-like 2 (EXTL2, EXTR2)

Function

• glycosyltransferase
• required for biosynthesis of heparan-sulfate
• responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) & alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains
• glycan metabolism; heparan sulfate biosynthesis
• the soluble form derives from the membrane form by proteolytic processing

Structure

• belongs to the glycosyltransferase 47 family

Compartment

• endoplasmic reticulum membrane
• single-pass type 2 membrane protein (putative)
• processed exostosin-like 2: secreted
• a soluble form is found in serum/plasma

Expression

ubiquitous

More general terms

• glycosyltransferase
• membrane protein
• anti-oncoprotein (tumor suppressor protein)
• glycoprotein

Additional terms

• exostosin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2135
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2135
• OMIM: https://mirror.omim.org/entry/602411
• UniProt: http://www.uniprot.org/uniprot/Q9UBQ6.html