trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26, glycine-tryptophan protein of 182 kD, GW182 autoantigen, protein GW1, EMSY interactor protein, TNRC6A, CAGH26, KIAA1460, TNRC6)

Function

• binds to mRNA
• role in structure/maintenance &/or stability of GW body structures
• phosphorylated

Structure

contains 1 RRM domain (RNA recognition motif)

Compartment

• cytoplasm, P-body
• in structures called GW bodies

Alternative splicing

named isoforms=5

Pathology

• antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome, ataxia & sensor neuropathy diseases that develop autoantibodies against protein of the GWB structure
• autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.

More general terms

• phosphoprotein
• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NDV7.html