regulator of differentiation 1 (ROD1, PTBP3)

Function

• role in regulation of differentiation (putative)
• in vitro, binds RNA, preferentially to both poly(G) & poly(U)

Structure

• contains 4 RRM domains (RNA recognition motif domains)

Alternative splicing

named isoforms=2

Expression

expressed in several hematopoietic cell lines

Pathology

• overexpressed, blocks differentiation of K562 leukemia cells following treatment with phorbol esters or sodium butyrate without affecting proliferation

More general terms

• RNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/607527
• UniProt: http://www.uniprot.org/uniprot/O95758.html