cytoplasmic polyadenylation element-binding protein (CPEB)
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Function
- enhances mRNA synthesis at the post-synaptic density
- prion-like domain that induces changes in other CPEB molecules in prion-like mechanism (i.e. protein in specific conformation induces similar conformation change in homologous proteins)
- may be involved in formation of long-term memory[2]
More general terms
More specific terms
- cytoplasmic polyadenylation element-binding protein 1 (CPE-binding protein 1, CPE-BP1, hCPEB-1, h-CEBP, CPEB1, CPEB)
- cytoplasmic polyadenylation element-binding protein 2 (CPE-binding protein 2, CPE-BP2, hCPEB-2, CPEB2)
- cytoplasmic polyadenylation element-binding protein 3 (CPE-binding protein 3, CPE-BP3, hCPEB-3, CPEB3, KIAA0940)
- cytoplasmic polyadenylation element-binding protein 4 (CPE-binding protein 4, CPE-BP4, hCPEB-4, CPEB4, KIAA1673)
References
- ↑ OMIM https://mirror.omim.org/entry/607342
- ↑ 2.0 2.1 Journal Watch 24(3):34, 2004 Si K et al A neuronal isoform of the aplysia CPEB has prion-like properties. Cell 115:879, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14697205 Si K et al A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Cell 115:893, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14697206