mitochondrial Na+/hydrogen exchanger NHA2; mitochondrial Na+/H+ exchanger NHA2; Na+/hydrogen exchanger-like domain-containing protein 2; Na+/H+ exchanger-like domain-containing protein 2; NHE domain-containing protein 2 (NHEDC2, NHA2, SLC9B2)

Function

• electroneutral exchange of protons for Na+ & Li+ across the inner mitochondrial membrane
• contributes to the organellar volume homeostasis
• required for osteoclast differentiation & bone resorption activity (putative)

Structure

• belongs to the Na+/H+ exchanger (TC 2.A.36.5.1) family

Compartment

mitochondrial membrane

Alternative splicing

named isoforms=2

Expression

detected in erythrocytes (at protein level)

More general terms

• mitochondrial protein
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1333
• UniProt: http://www.uniprot.org/uniprot/Q86UD5.html