Fc receptor-like protein 1 (FcR-like protein 1, FcRL1, Fc receptor homolog 1, FcRH1, IFGP family protein 1, hIFGP1, immune receptor translocation-associated protein 5, FCRL1, FCRH1, IFGP1, IRTA5)

Function

• may function as an activating coreceptor in B cells

may function in B cells activation & differentiation

• phosphorylated on tyrosines upon activation

Structure

contains 3 Ig-like C2-type domain (immunoglobulin-like)

Compartment

cell membrane

Alternative splicing

named isoforms=4

Expression

• primarily expressed in secondary lymphoid tissues by mature subsets of B cells
• detected in spleen, lymph node, heart, skeletal muscle, kidney, liver & placenta
• specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level)
• down-regulated in activated B cells

More general terms

• Fc receptor
• glycoprotein
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1153
• OMIM: https://mirror.omim.org/entry/606508
• UniProt: http://www.uniprot.org/uniprot/Q96LA6.html